Fernando Pessoa famously wrote and believed that nothing at all matters. And in a sense, it is true.

The opposite of that view is that everything matters. It is equally true. Reality, existence itself is a paradox, and if an answer to a question about life and reality isn't paradoxical, it tends to be a false answer.

If it is so, then we are unequipped to fully understand reality because our minds cannot solve the paradox.

We can only acknowledge it.